1. Hemophilia is caused due to a deficiency of which clotting factor?
A. Factor VIII or IX
B. Factor II
C. Factor V
D. Factor XII
Answer: A. Factor VIII or IX
2. Which chromosome carries the gene for hemophilia?
A. X chromosome
B. Y chromosome
C. Chromosome 7
D. Chromosome 22
Answer: A. X chromosome
3. What is the mode of inheritance of color blindness?
A. Autosomal dominant
B. Autosomal recessive
C. X-linked recessive
D. Y-linked
Answer: C. X-linked recessive
4. Which gender is more frequently affected by hemophilia?
A. Males
B. Females
C. Both equally
D. None
Answer: A. Males
5. Which type of hemophilia is more common?
A. Hemophilia A
B. Hemophilia B
C. Hemophilia C
D. All are equally common
Answer: A. Hemophilia A
6. In color blindness, which color perception is most commonly defective?
A. Blue
B. Green
C. Yellow
D. Black
Answer: B. Green
7. A woman carrier for hemophilia marries a normal man. What is the probability of their male child being hemophilic?
A. 25%
B. 50%
C. 75%
D. 100%
Answer: B. 50%
8. What is the genotype of a color-blind male?
A. XCB^{CB}CBY
B. XN^{N}NY
C. XN^{N}NXCB^{CB}CB
D. XCB^{CB}CBXCB^{CB}CB
Answer: A. XCB^{CB}CBY
9. A male inherits hemophilia from which parent?
A. Mother only
B. Father only
C. Both parents
D. Neither parent
Answer: A. Mother only
10. What percentage of sons will inherit color blindness from a carrier mother and a normal father?
A. 25%
B. 50%
C. 75%
D. 100%
Answer: B. 50%
11. Why are females less frequently affected by X-linked disorders?
A. They have two X chromosomes.
B. Their genes are more resistant.
C. They lack recessive traits.
D. They do not inherit X-linked traits.
Answer: A. They have two X chromosomes.
12. Hemophilia is often called the “royal disease” because it was common in which royal family?
A. British
B. Russian
C. French
D. Spanish
Answer: B. Russian
13. A man with normal vision marries a carrier woman for color blindness. What is the probability of a daughter being color-blind?
A. 0%
B. 25%
C. 50%
D. 100%
Answer: A. 0%
14. Which is true for a carrier female for hemophilia?
A. She does not show symptoms.
B. She shows mild symptoms.
C. She is completely affected.
D. She cannot pass it to offspring.
Answer: A. She does not show symptoms.
15. Which combination will never produce a hemophilic child?
A. Normal father and carrier mother
B. Hemophilic father and normal mother
C. Carrier mother and hemophilic father
D. Both parents normal
Answer: D. Both parents normal
16. Which of the following is NOT an X-linked disorder?
A. Hemophilia
B. Color blindness
C. Duchenne muscular dystrophy
D. Sickle cell anemia
Answer: D. Sickle cell anemia
17. The gene responsible for red-green color blindness is located on which chromosome?
A. X chromosome
B. Y chromosome
C. Chromosome 12
D. Chromosome 15
Answer: A. X chromosome
18. A color-blind woman marries a normal man. What will be the vision of their daughters?
A. Normal vision
B. All carrier
C. All color-blind
D. 50% carrier, 50% normal
Answer: B. All carrier
19. The chance of a female offspring being affected by an X-linked recessive disorder is highest when:
A. Both parents are carriers.
B. Father is affected and mother is a carrier.
C. Father is normal and mother is a carrier.
D. Both parents are normal.
Answer: B. Father is affected and mother is a carrier.
20. Which test can detect color blindness?
A. Ishihara test
B. ECG
C. MRI
D. EEG
Answer: A. Ishihara test
21. What is the genotype of a female carrier for hemophilia?
A. XH^{H}HXh^{h}h
B. Xh^{h}hY
C. XH^{H}HY
D. XH^{H}HXH^{H}H
Answer: A. XH^{H}HXh^{h}h
22. Hemophilia B is also known as:
A. Christmas disease
B. Valentine disease
C. Bleeding syndrome
D. Hemostasis disorder
Answer: A. Christmas disease
23. How many types of cones are defective in total color blindness?
A. One
B. Two
C. Three
D. None
Answer: C. Three
24. A male with color blindness marries a carrier female. What is the probability of their sons being color-blind?
A. 25%
B. 50%
C. 75%
D. 100%
Answer: B. 50%
25. Hemophilia is categorized as:
A. A bleeding disorder
B. A clotting disorder
C. Both A and B
D. None of the above
Answer: C. Both A and B
26. Which mechanism explains the inheritance of X-linked traits?
A. Independent assortment
B. X-inactivation
C. Crossing over
D. Non-disjunction
Answer: B. X-inactivation
27. Which blood component is most affected in hemophilia?
A. Platelets
B. Plasma proteins
C. White blood cells
D. Red blood cells
Answer: B. Plasma proteins
28. Color blindness prevalence is higher in males because:
A. They have one X chromosome.
B. They lack a Y chromosome.
C. They have more recessive traits.
D. It is autosomal.
Answer: A. They have one X chromosome.
29. Hemophilia patients are at risk of which complications?
A. Excessive bleeding
B. Internal bleeding
C. Joint damage
D. All of the above
Answer: D. All of the above
30. Which type of hemophilia is caused by a deficiency of Factor IX?
A. Hemophilia A
B. Hemophilia B
C. Hemophilia C
D. None of the above
Answer: B. Hemophilia B
